Of sedating antihistamines

Chronic urticaria may benefit from doxepin, a tricyclic antidepressant with potent antihistamine properties.

Because of its significant sedative properties, it should be given at bedtime.

Anyway I'd like to know which of them (regardless as their branding as 'antihistamines') has the strongest affiliations with these receptors known for producing hypnotic properties.

From what I can tell I think the list beginning with the strongest goes something like this: Quetiapine (seroquel) Mirtazipine (remeron) (from experience) Hydrazine Promethazine (from inference from the internet's experience) --------- Anything else I'm missing here?

The efficacy and safety of omalizumab for CIU was demonstrated in two clinical studies that showed omalizumab significantly improved the mean weekly Itch Severity Score (ISS) from baseline by 9.4-9.6 in the 300-mg treatment arm (The dosing for use in asthma is based on weight and Ig E levels, but omalizumab can be administered in 150- or 300-mg doses and, unfortunately, there are no clinical markers that can predict whether or not it will be effective.

Although the evidence supporting its efficacy in treating urticaria is of high quality, the cost of the drug may preclude its use in many patients.

Currently the only FDA-approved histamine antagonist medications block the effects of histamine at H1 or H2 receptor sites.Topical preparations (ointments and creams) are often applied to insect bites but are not very effective as the antihistamine chemical does not penetrate the skin well.Sedating antihistamines should not be used in children under the age of 2 years for any reason and should not be used in children under 6 years for cough and cold symptoms.I can't tell if the sedative properties of certain antihistamines results from their H1 antagonism or if it's because of their cross effect with antagonizing the adrenergic receptors.Are all H1 antagonists innately sedating or is it just the first generation ones?

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This means it has an effect on small blood vessels, resulting in dilated capillaries (redness), and leakage of protein-rich fluid into surrounding skin (swelling).

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